Hi.
I quote from your output:
PID USER PR NI VIRT RES SHR S %CPU %MEM TIME+ COMMAND
22953 andru 15 0 10100 5316 9464 S 3.7 0.6 2:02.39 mpg123
1067 root 5 -10 595m 58m 539m S 3.3 6.6 391:41.29 XFree86
1176 andru 15 0 47488 26m 13m S 1.0 3.0 11:52.32 gnome-terminal
25063 root 17 0 2004 1096 1792 R 0.7 0.1 0:00.03 top
The kernel is now tuned to give much more priority to reniced tasks and it is not recommended to run your X server nice -10. This is the cause of your problem as X is starving your audio application. Some distributions do this by default to get around the limitations of the old cpu scheduler not being able to make X smooth enough at nice 0. This hack/workaround is no longer recommended for 2.6 kernels. You will find nice performance of X at nice 0 now and audio will not skip when the nice value of X is the same as your audio application.
Con